Particle size analysis can be done by various methods. However, the two below methods are the most popular:
Laser Diffraction Technique
Microscopy Technique
In the Laser Diffraction Technique, it gives the information of Particle only basis of their size (No difference between the single particles and the agglomeration). That’s because of its diffraction technique the laser falls on the particle where it has created a certain angle and provides the image of a particle through the detector on the system, where the agglomerates are considered as bigger particles and the single particles are considered as small particle according to its size distribution range). It converts an equivalent sphere. The value of size distribution will provide only the basis of volumetric SED.
In the Microscopic Technique, it is only a direct method technique where transparency is available and every particle is visible, hence the analysis can be done not only on the basis of size but also on the basis of shape. Hence, we are getting the complete morphological details, such as the Intensity of light on particles, Convexity, Solidity, Aspect ratio, Length and Width etc.
In ImageProVision applications or software provides detailed information about particle based on their: Length, Width, Aspect ratio, Intensity of light on particles, Convexity, Solidity, CED (Circular equivalent diameter) also based on Volumetric SED (Spherical equivalent Diameter).
Since Microscopic Technology with IPV software is an image analysis technique, that has full transparency, because of the identification of single particles and agglomerates are easy to observe and differentiate, easy to get elongated particles, rectangular particles, API’s (Active Pharmaceutical Ingredient), globules etc. Therefore, you can trace every individual particle.
