Hot Stage Microcopy

Hot Stage Microscopy is a type of microscopy used in the analysis of materials that are temperature-sensitive or that require a temperature-controlled environment.

It is used to study the physical and chemical properties of materials or decomposition of organic compounds or the formation of new compounds as they are heated, cooled, or maintained at a specific temperature.

Hot Stage Microscopy is an invaluable tool for the pharmaceutical industry as it helps to identify the melt and crystallization behavior of drugs and other chemicals. This enables scientists to understand the structure of a material and how it will behave when exposed to heat. This helps to develop and optimize drug formulations to ensure that they are stable and effective at the desired temperatures. Hot Stage Microscopy also allows the study of phase transitions which can help to identify polymorphism or solvate formation which can have a major impact on the efficacy of a drug. Finally, it can be used to investigate the effects of impurities on the physical properties of a material, allowing for the optimization of the quality of a product.

Hot-stage microscopy analysis is used as a routine analytical method in the pharmaceutical industry. The sample is placed on a sample holder, which is then placed into a stage that is heated or cooled to the desired temperature ramps. The sample is viewed through a microscope while it is heated or cooled, allowing researchers to observe the changes in physical characteristics as the temperature is changed. It is frequently used as a complementary technique to DSC during compatibility analyses.

Image Provision is offering a complete system consisting of Hot-stage Microscopy coupled with a camera system for image analysis that allows the identification of API particles in mixtures or in disintegrated tablets and the analysis of changes in various particles in a formulation concerning temperature and time.

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